You have to start Jacobs. Ed talked him down all offseason, so it would make for a great story either way: if he now helps you beating him. Or busts entirely, giving Ed a big W. 
ETN carries a question mark after last week. I’d bench him for another week or two, if you have alternatives (and you do).
Alongside Jacobs, I would start Samuel, or Hollywood Brown, if you believe Samuel’s week 1 performance was a fluke (I don’t think so, tbh).