2 RB, 2 WR, 2 FLEX. Who are you picking?

Dalvin Cook vs Detroit
Henderson Jr. Vs Seattle
Edmonds vs 49er
Damien Williams vs Raiders
Alex Collins vs Rams

JaMarr Chase vs GB
Deandre Hopkins vs 49er
Brandon Cooks vs New England
Tim Patrick vs Pittsburgh
Hunter Renfrow vs Chicago
Devonta Smith vs Carolina
Aiyuk vs Cardinals

RB: Cook and Williams.
WR: Chase and Hopkins.
Flex: Henderson and Smith or Renfrow.

Smith is the high upside player, while Renfrow is the solid floor player. Whichever you prefer.