Commanders (-7) vs. Cardinals: 1 p.m. Sunday
Will the Cardinals finish with the worst record in the NFL in Jonathan Gannon’s first season? Being touchdown underdogs against Washington says a lot.
Falcons (-3.5) vs Panthers: 1 p.m. Sunday
Let the Bijan Robinson Rookie of the Year run commence in Atlanta.
Browns vs. Bengals (-2.5): 1 p.m. Sunday
Deshaun Watson vs. Joe Burrow in a divisional matchup in Cleveland. This game is easily the best of the 1 p.m. slate.
Ravens (-10) vs. Texans: 1 p.m. Sunday
This is the biggest number of Week 1. C.J. Stroud gets his first NFL start, and new Texans coach DeMeco Ryans gets his first NFL game as a head coach. Waiting for them is Lamar Jackson and Co.
Colts vs. Jaguars (-4.5): 1 p.m. Sunday
Doug Pederson’s Jaguars made some noise last season. Will they get off to a good start Sunday on the road?
Steelers vs. 49ers (-2.5): 1 p.m. Sunday
The 49ers are right behind the Eagles on the NFC odds board, but they start the season as a short road favorite in Pittsburgh.
Vikings (-6) vs. Buccaneers: 1 p.m. Sunday
The Tom Brady era is over in Tampa, while Minnesota has playoff expectations once again.
Saints (-3) vs. Titans: 1 p.m. Sunday
Derek Carr is the new quarterback in town in New Orleans. The Titans, meanwhile, added DeAndre Hopkins to a team that went 7-10 last season.
Bears (-1) vs. Packers: 4:25 p.m. Sunday
Speaking of era ending. The Aaron Rodgers era is over in Green Bay, and the Jordan Love era begins with a divisional, coin-flip road game in Chicago.
Seahawks (-5.5) vs. Rams: 4:25 p.m. Sunday
Star wide receiver Cooper Kupp will see a specialist for his hamstring injury. Without him, the Rams’ offense is much weaker.
Chargers (-3) vs. Dolphins: 4:25 p.m. Sunday
A preview of an AFC playoff matchup? Both were wild-card teams last season.
Broncos (-3.5) vs. Raiders: 4:25 p.m. Sunday
Can Sean Payton help the Broncos and Russell Wilson turn things around?
Patriots vs. Eagles (-4): 4:25 p.m. Sunday
The NFC champion Eagles will likely be favored in their first five contests, starting Sunday at New England.
Giants vs. Cowboys (-3): 8:20 p.m. Sunday
NBC’s Sunday Night Football schedule kicks off with a rivalry NFC East matchup at MetLife Stadium. Which team will be hunting the Eagles for the top spot in the division? We’ll have a good answer by midnight.
Jets vs. Bills (-2.5): 8:20 p.m. Monday
Rodgers gets his first start with the Jets in a big one: With division rival Buffalo and Josh Allen coming to town. The Bills have Super Bowl aspirations, and the Jets want to show they’re going to be in the hunt for a playoff spot.
Just for fun pick your best bets for this weekend, up to 3 games.