Drop Aiyuk or Alex Collins?
As long as Chis Carson is out, Collins is a keeper, albeit not the best RB.
On the other hand, Aiyuk has some kind of issue that isn’t being reported, and I don’t think it’s health. Until Aiyuk shows he can put up back-to-back decent games, he’s bench fodder hoping to become a lottery ticket. If you can’t afford the bench space to stash him, then feel free to move on to somebody who actually plays.